Weight Loss Peptide Stack Protocol

One peptide handles one problem. A stack hits multiple mechanisms simultaneously: appetite, direct lipolysis, GH for body composition. Here's how to build a weight loss stack from compounds that actually work.

Layer 1: appetite (foundation)

[[Tirzepatide|10]] is the foundation of any weight loss stack. Dual GLP-1/GIP agonist suppresses appetite, slows stomach, improves insulin sensitivity. 22.5% weight loss in SURMOUNT-1. Dosing: start 2.5mg/week, titrate to 5-15mg. This is your heavy artillery.

Layer 2: direct lipolysis (accelerator)

[[AOD-9604|16]] adds what tirzepatide doesn't do: direct fat mobilization via beta-3 adrenergic receptors. Doesn't touch appetite, blood sugar, or IGF-1. Dosing: 250-500mcg/day fasted morning. Combo: tirzepatide cuts calorie intake, AOD-9604 speeds up burning stored fat.

Layer 3: GH optimization (bonus)

[[Ipamorelin|17]] raises GH, which improves fat-to-muscle ratio, speeds recovery, and improves sleep. Dosing: 200-300mcg pre-bed fasted. Optionally add morning dose.

Sample stack

Morning fasted: AOD-9604 300mcg + Ipamorelin 200mcg (subQ).
Weekly: Tirzepatide 5-10mg (subQ).
Pre-bed: Ipamorelin 200mcg (subQ, 2+ hours after food).

Course: 8-12 weeks. Tirzepatide can continue longer; ipamorelin and AOD cycle with 4-week breaks.

Want a stack built for your situation? Reach out to us and we'll help with doses and timing.

This article is for educational purposes. Peptides are intended for research use. Consult a healthcare professional before starting any protocol.