GH Peptides: GHRP vs GHRH vs Fragments

Three approaches to growth hormone optimization. Each works differently, and the choice depends on your goal: general GH boost, targeted fat loss, or maximum synergistic effect.

GHRP: "release what you have"

GHRPs work through ghrelin receptors, telling the pituitary to release stored GH. [[Ipamorelin|17]] is the cleanest GHRP: no cortisol, no prolactin, no hunger spike. Dosing: 200-300mcg 2-3x daily fasted, 8-12 week cycles.

GHRH: "produce more"

GHRH analogs stimulate the pituitary to produce AND release GH. [[Tesamorelin|18]] with FDA acknowledgment, reduces visceral fat by 15-18%. Dosing: 1-2mg/day. More physiological secretion pattern than GHRP.

Fragments: "just fat"

[[AOD-9604|16]] is a GH fragment (amino acids 177-191) responsible only for lipolysis. No impact on IGF-1, glucose, or tissue growth. Pure fat burning via beta-3 adrenergic receptors. 250-500mcg/day fasted.

How to choose

• General GH boost (sleep, recovery, body comp) → Ipamorelin or tesamorelin stack
• Visceral fat + cognitive function → Tesamorelin
• Fat loss only, no GH side effects → AOD-9604
• Maximum output → GHRP+GHRH stack (ipamorelin + tesamorelin)

Need help choosing? Reach out to us.

This article is for educational purposes. Peptides are intended for research use. Consult a healthcare professional before starting any protocol.