Cagrilintide pen

Chemical information:CAS: 1415456-99-3Molecular formula: C174H271N53O51Molecular weight: 3900.2 DaThis entry summarizes published peptide research and laboratory handling notes. Research use only — not for human consumption, diagnostic or therapeutic use. Cagrilintide is a long-acting synthetic analogue of amylin, a pancreatic hormone co-secreted with insulin by beta cells. Its molecular design combines amylin-receptor and calcitonin-receptor agonism with a fatty-acid side chain that extends half-life to approximately one week, allowing once-weekly dosing. In research studies cagrilintide has been investigated both as monotherapy for weight management and in combination with semaglutide (branded CagriSema) for additive effects on body weight. Mechanism of action Cagrilintide activates amylin and calcitonin receptors in the area postrema and hypothalamus to slow gastric emptying, promote satiety, and reduce food intake. Because amylin signalling is complementary to GLP-1 signalling, combining cagrilintide with a GLP-1 receptor agonist produces additive effects on appetite suppression without doubling the side-effect burden of either molecule alone. Evidence from peer-reviewed research A 2021 Phase 1b paper in The Lancet reported safety, tolerability, and pharmacokinetics of cagrilintide plus semaglutide 2.4 mg for weight management. A companion 2021 Lancet Phase 2 dose-finding trial of once-weekly cagrilintide monotherapy showed placebo-subtracted weight loss of approximately 6–10% at the higher doses. Both papers established cagrilintide as a leading candidate in the amylin-analogue class. Typical research protocols In published studies cagrilintide is administered subcutaneously once weekly with stepwise dose escalation to minimise gastrointestinal side-effects. Because the peptide has a basic isoelectric point, it is reconstituted with acidic water rather than bacteriostatic water to maintain solubility and stability. Quality and purity PEPTEX cagrilintide is synthesised to ≥99% purity, lyophilised under inert gas, and certified by HPLC. Research use only. Storage and handling Store lyophilised cagrilintide at −20 °C, protected from light, for up to 24 months. After reconstitution with acidic water, store at 2–8 °C and use within 12 weeks. Related research compounds: Tirzepatide, Retatrutide, Bacteriostatic Water. All PEPTEX research peptides ship with batch-specific Certificate of Analysis (HPLC ≥99%). Lyophilized form, EU warehouse, 24-hour dispatch. Research use only (RUO).

Price: EUR | Brand: PEPTEX | In Stock | EU-wide delivery, 3-5 business days

Available Sizes

• 5mg — 159 EUR
• 10mg — 219 EUR