Epithalon pen

Chemical information:CAS: 307297-39-8Molecular formula: C14H22N4O9Molecular weight: 390.35 DaThis entry summarizes published peptide research and laboratory handling notes. Research use only — not for human consumption, diagnostic or therapeutic use. Epithalon, also spelled Epitalon, is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Professor Vladimir Khavinson at the St Petersburg Institute of Bioregulation and Gerontology. It is the synthetic analogue of Epithalamin, a polypeptide extract originally isolated from the pineal gland. Over more than two decades of published research, Epithalon has been investigated for its effects on telomerase activity, circadian and neuroendocrine regulation, and lifespan in rodent models. Mechanism of action Khavinson and colleagues have shown that Epithalon activates telomerase in somatic cells and restores telomere length in cultured human fibroblasts and leukocytes. In parallel, the peptide normalises the age-related decline in pineal melatonin production, which in turn restores the amplitude of circadian rhythms and several neuroendocrine axes (growth-hormone, cortisol, and thyroid). These two mechanisms — telomere maintenance and pineal restoration — are the subject of the bulk of published research on Epithalon. Evidence from peer-reviewed research A 2003 paper in Neuro Endocrinology Letters reported that Epithalon activated chromatin at advanced age in peripheral blood cells of elderly donors. A companion paper in Biogerontology (2003) documented extended median lifespan and reduced spontaneous tumour incidence in female SHR mice. A 2006 review in the Annals of the New York Academy of Sciences summarised the body of Russian and international research on the peptide, and a 2005 paper in Experimental Gerontology showed that pineal peptides restored hormonal function in aged primates. Links to these papers are available in the Research References section. Typical research protocols Published protocols in rodent studies typically administer Epithalon in short cycles — ten to twenty days of daily injection followed by extended rest periods — mimicking a seasonal pattern. In translational laboratory use, researchers often run short courses of low-milligram doses once or twice a year. Quality and purity PEPTEX Epithalon is synthesised to ≥99% purity under ISO-compliant conditions, lyophilised, and certified by HPLC. Research-grade use only. Storage and handling Store the lyophilised peptide at −20 °C, protected from light. After reconstitution with bacteriostatic water, store at 2–8 °C and use within 12 weeks. The small tetrapeptide is relatively stable in solution compared with longer peptides, but repeated freeze–thaw should still be avoided. Related research compounds: NAD+, GHK-Cu. All PEPTEX research peptides ship with batch-specific Certificate of Analysis (HPLC ≥99%). Lyophilized form, EU warehouse, 24-hour dispatch. Research use only (RUO).

Price: EUR 189.00 | Brand: PEPTEX | In Stock | EU-wide delivery, 3-5 business days

Available Sizes

• 50mg — 189 EUR